Rat Prolactinoma Cell Growth Regulation by Epidermal Growth Factor Receptor Ligands
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چکیده
منابع مشابه
Rat prolactinoma cell growth regulation by epidermal growth factor receptor ligands.
Epidermal growth factor (EGF) regulates pituitary development, hormone synthesis, and cell proliferation. Although ErbB receptor family members are expressed in pituitary tumors, the effects of EGF signaling on pituitary tumors are not known. Immunoprecipitation and Western blot confirmed EGF receptor (EGFR) and p185(c-neu) protein expression in GH3 lacto-somatotroph but not in adrenocorticotro...
متن کاملGrowth Factor Receptor Ligands Rat Prolactinoma Cell Growth Regulation by Epidermal
Epidermal growth factor (EGF) regulates pituitary development, hormone synthesis, and cell proliferation. Although ErbB receptor family members are expressed in pituitary tumors, the effects of EGF signaling on pituitary tumors are not known. Immunoprecipitation and Western blot confirmed EGF receptor (EGFR) and p185 protein expression in GH3 lacto-somatotroph but not in adrenocorticotropic hor...
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Methods. Proliferating human RPE cells were exposed to varying concentrations of exogenous basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF) at different media oxygen tensions (16 to 147 mm Hg) and cell counts determined after 4 days. Receptor expression was determined by affinity cross-linking and saturation binding studies on confluent RPE cultures exposed to varying medi...
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Epidermal growth factor receptor (EGFR) and ErbB2 readily form heterodimers when both are expressed in the same cell and the EGFR is activated by one of its ligands. Our data show that such heterodimers are constitutively formed also in a ligand-independent manner on overexpression of EGFR and ErbB2 in porcine aortic endothelial cells. Interestingly, cross-linking experiments showed that incuba...
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A CRITICAL ISSUE IN UNDERSTANDING how the mammalian kidney responds to pathological states and nephrotoxic chemicals involves the identification of modulating agents, growth factors, and signaling pathways that regulate responses. Although some of the modulating agents identified, including chemicals such as thiol reductants (e.g., glutathione, N-acetyl-L-cysteine) or -tocopherol, can have a si...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2008
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-08-0508